BAX and skin neoplasm: Furthermore, UA induced apoptosis in melanoma cells, which was mediated by the modulation of the apoptotic and inflammatory pathways, including the inhibition of NF-κB, the induction of S-phase cell cycle arrest, and the alteration of the Bax/Bcl-2 balance, showing its potential as a chemopreventive and therapeutic agent against skin cancer (Figure 5).