Group 3 MBs, marked by high-level amplifications of transcription factor orthodenticle homeobox 2 (OTX2) and proto-oncogene c-MYC, are frequently associated with elevated OTX2 and c-MYC expression, leading to genomic instability and the poorest prognosis among all subgroups [10,12,13,14,15,16]. Here, OTX2 is linked to Mobius syndrome.