In order to explore the presence of the OTX2-mTOR signaling pathway interaction in human MB tumors, we conducted an extensive in silico data analysis and found a significant positive correlation between OTX2 and mTOR mRNA expressions across a substantial dataset of human tumor samples (n = 952) obtained from three independent datasets, as depicted in Figure 8: Northcott dataset (N = 103) [44], the Cavalli dataset (N = 763) [16], and the Okonechnikov dataset (N = 86) [45]. This evidence concerns the gene OTX2 and neoplasm.