CHRNA7 and myocardial infarction: Two previous myocardial infarction studies have shown that treatment with PNU-120596 (positive allosteric modulator of the α7nAChR) and PNU-282927 (selective α7nAChR agonist) can decrease both the infarct size and the production of proinflammatory cytokines after myocardial infarction in rats using a reperfusion injury model [13,14].