Recent studies have shown that treatment with the α7nAChR agonists GTS-21 and PNU-282927 can acutely decrease infarct size and the production of serum proinflammatory cytokines after myocardial infarction in rats [18,19], where histological assessments revealed a decreased infarct area in the rats treated with GTS-21 and PNU-282987 1.5 and 2.5 h post infarction, respectively. Here, CHRNA7 is linked to myocardial infarction.