Although there is no direct evidence of immune privilege collapse in vitiligo, it may be hypothesized that immune privilege collapse occurs in only a small portion of the lower HBg and hair germ, where melanocyte stem cell precursors reside, leading to (1) enhancement of IFN-γ signaling pathways and (2) exposure of self-antigens to cytotoxic T lymphocytes, thereby causing subsequent melanocyte instability in vitiligo pathogenesis, as Boniface et al. reported [107]. Here, IFNG is linked to vitiligo.