AGT and cardiac hypertrophy: In a mouse model resembling the cardiometabolic HFpEF phenotype, aged female mice were fed with a high-fat diet (HFD) and Ang II, and the GLP-1 RA liraglutide attenuated the cardiometabolic dysregulation and reduced cardiac hypertrophy, myocardial fibrosis, atrial weight, natriuretic peptide levels, and lung congestion [164].