AT1R activation increases aldosterone and anti-diuretic hormone production, sympathetic nervous system tone, BP, vasoconstriction, cardiac hypertrophy, fibrosis, inflammation, vascular smooth muscle cell dedifferentiation, and reactive oxygen species production, and at the same time, reduces parasympathetic nervous system (PSNS) tone, baroreflex sensitivity, nitric oxide production, and natriuresis [135]. The gene discussed is AGTR1; the disease is cardiac hypertrophy.