In humans, Mertk has been linked by GWAS studies as a novel genetic risk for SLE and end-stage renal disease [12], and an increase in the soluble ectodomain of Mertk has been observed in SLE [13], suggesting translational relevance to the mouse studies in the relationship to the immunopathogenesis of SLE. The gene discussed is MERTK; the disease is stage 5 chronic kidney disease.