Itani et al. uncovered a novel role of immunological memory in hypertension using two models of repeated hypertensive stimulation [20]: (1) high-dose ANG II infusion followed by low-dose ANG II infusion; (2) low-dose N(ω)-nitro-L-arginine methyl ester (L-NAME) treatment followed by high-salt (HS) exposure. The gene discussed is AGT; the disease is hypertensive disorder.