In this study, we observed that macrophages can induce EMR1 expression in EMR1KO cells also, and inhibition of the JAK2/STAT3 pathway can suppress EMR1 expression in cancer cells, suggesting a potential link between EMR1 activation and the transcriptional regulation mediated by JAK2/STAT3 signaling in cancer cells. The gene discussed is ADGRE1; the disease is cancer.