Furthermore, de novo mutations in the ADNP gene are associated with ADNP syndrome (also known as Helsmoortel Van Der Aa syndrome), which manifests a variety of clinical symptoms, including global developmental delays, autistic/intellectual disability, and motor dysfunctions [25,26,27,28]. Here, ADNP is linked to ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder.