Interestingly, Ding et al. [30] showed in colorectal cancer that the lncRNA encoded by the CRNDE gene can epigenetically inhibit the expression of the CDKN1A gene, the protein product of which, p21, is a tumor suppressor, interacting with TP53, involved in the control of both aforementioned checkpoints, too. The gene discussed is TP53; the disease is colorectal cancer.