CDKN1A and lung adenocarcinoma: A similar finding was made in the lung adenocarcinoma [38], where it was established that, by interacting with the polycomb repressive complex 2 (PRC2), which maintains overall transcriptional repression in the genome, CRNDE lncRNA may down-regulate the CDKN1A expression, leading to a low histological differentiation of the tumor, its increased resistance to radiotherapy and tendency for metastasis.