Other teams showed that increased expression of CRNDE stimulates cancer cells to divide, invade other tissues, and metastasize by activation of the Wnt/ß-catenin [13,14], PI3K/AKT/mTOR [15,16], Ras/MAPK [17,18] and Notch1 pathways [19]. The gene discussed is NOTCH1; the disease is cancer.