PTEN and cholesteryl ester measurement: As such, plasma EVs from CE patients were enriched in transcripts involved in leukocytes cell–cell adhesion (IGFBP-2, PECAM-1), hemostasis (PF4V1, PF4), T cell activation (IGFBP-2), neutrophil migration (PECAM-1), axonal regeneration (PTEN, MAP2K1), and cardiomyocyte proliferation (PTEN, Figure 3).