This effect may stem from the cytotoxic action of anticancer drugs, as other medications such as topoisomerase inhibitors [203], 5-fluorouracil [204], epidoxorubicin [39], as well as paclitaxel and carboplatin [205], have also been shown to increase CXCL1 expression in cancer cells across different types of tumors. This evidence concerns the gene CXCL1 and cancer.