CXCL1 and cancer: Also, high CXCL1 expression in glioblastoma tumors leads to an increase in the number of macrophages with M2 polarity, as well as granulocytic-myeloid-derived suppressor cells (G-MDSC) and monocytic-myeloid-derived suppressor cells (M-MDSC) [51], which indicates an enhancement of cancer immune evasion.