In this current work, we expound upon the significance of CXCL1 in the remaining array of malignancies, including bladder cancer, glioblastoma, hemangioendothelioma, hematolymphoid tumors (leukemias), Kaposi’s sarcoma, lung cancer, osteosarcoma, renal cancer, and various skin cancers like malignant melanoma, basal cell carcinoma, cutaneous squamous cell carcinoma, as well as thyroid cancer. This evidence concerns the gene CXCL1 and melanoma.