The production of large amounts of CXCL1 in a lung adenocarcinoma tumor leads to the recruitment of G-MDSC to the lymph node at an early stage of metastasis [152]; these cells contribute to lymph node metastasis, which is related to the secretion of TGF-β1 by these cells. The gene discussed is CXCL1; the disease is lung adenocarcinoma.