CXCL1 expression in malignant melanoma cells is also dependent on CXCL1 itself inducing CXCR2 activation, which results in increased NF-κB activity [177,179,186] in a mechanism dependent on Ras and p38 MAPK, which thus increases CXCL1 expression. This evidence concerns the gene CXCL1 and melanoma.