PRKN and Parkinson disease: The PD-related changes in MT biogenesis, including (a) a reduction in MT complex I content in the SN and (b) reduced levels of Parkin associated with the accumulation of a Parkin-interacting substrate that downregulates PGC1, are also present in animal models of advanced T2D stages [27,285,286,287,288,289,290,291].