In the present study, the CD3- deficiency-mediated protective effects against AngII-induced AAA were partially attenuated by SIRT1 and SIRT6 inhibitors, respectively, suggesting that the NAD+/SIRT1 and NAD+/SIRT6 signaling pathways may play a role in AngII-induced AAA formation. The gene discussed is AGT; the disease is triple-A syndrome.