Interestingly, among the 24 PC genes with restored expression, seven genes (Abr, Calb1, Htr1b, Itpr1, Kcnip1, Kcnma1, and Mtss1) were part of a group of 80 PC-type-specific downregulated genes common to the SCA1, SCA2, and SCA7 mouse models and composed an ataxia molecular signature [23]. The gene discussed is KCNMA1; the disease is cerebellar ataxia.