ATXN7 and spinocerebellar ataxia 7: To assess whether AAV-shA4 treatment ameliorates the expression of deregulated genes, we performed RNA-seq analysis of the cerebellum of AAV-shA4-treated SCA7 mice at 23 weeks post-injection and compared them to AAV-shSCR-treated SCA7 mice and age-matched untreated WT mice.