The top 20 downregulated genes included BMP8A (a member of the transforming growth factor-β (TGF-β) family that promoted proliferation and inhibited apoptosis of renal cell carcinoma [41]) and MAP1B (a member of the MAP family that plays a role in the proliferation and invasive abilities of urothelial carcinoma cells [42]). The gene discussed is BMP8A; the disease is hereditary clear cell renal cell carcinoma.