NUPR1 and melanoma: In HL-60 cells, the top 20 upregulated genes included NUPR1 (a transcription factor that was involved in regulating apoptosis and DNA repair in cervical cancer cells [43,44]) and THBS1 (an extracellular glycoprotein that induced apoptosis in granulosa cells and induced apoptosis in the endothelial cells of mice with melanoma [45,46,47]).