RARRES2 and Alzheimer disease: The present study found that CMKLR1-expressed astrocytes are upregulated, whereas chemerin in neurons is downregulated in APP/PS1 mice, suggesting that the imbalance of chemerin/CMKLR1 and Aβ/CMKLR1 axes in astrocytes results in the migration and accumulation of astrocytes toward Aβ plaques in AD pathological process (Figure 8).