The cGAS-STING pathway has been implicated in neuroinflammation by its regulation of the immune functions of glial cells in several disease models, including neurodegenerative diseases (such as Alzheimer’s disease) [33,34,50,51], major depressive disorder (MDD) [52], experimental autoimmune encephalomyelitis (EAE) [36], ischemia/reperfusion-induced or traumatic brain injury [53,54,55], and brain metastasis [37]. Here, STING1 is linked to early-onset autosomal dominant Alzheimer disease.