INSR and metastatic neoplasm: The genes that were upregulated in the monosomy 3/metastatic tumors (PFKP, NUP88) exhibited an average fold change (FC) of 2.06 ± 0.82, whereas the downregulated genes (INSR, RBKS, and ZBTB20) differed by an average of −1.87 ± 0.44-fold (Figure 1B).