The most relevant biological processes, pathways, and phenotypes involved the “positive regulation of the glycolytic and purine nucleotide metabolic pathways”, “phosphofructokinase activity”, “insulin-like growth factor II/I/AMP binding”, “Pentose phosphate/HIF-1/AMPK pathways”, “galactose, fructose, and mannose metabolism”, “insulin receptor substrate activation”, “signal attenuation/insulin receptor recycling”, and “diabetes (type 2)” (Figure 1C). The gene discussed is INSR; the disease is diabetes mellitus.