In contrast, 7 and 21 days after the contusion, WT mice presented a significant increase in their Hmax/Mmax ratio compared to their basal values (p < 0.05 basal vs. 7 dpi; p < 0.05 basal vs. 21 dpi), reaching the same levels of hyperreflexia than Crtl1 KO mice at 7, 21 and 35 dpi. The gene discussed is HAPLN1; the disease is Hyperreflexia.