In this experimental pathology analysis, MPO KO mice were shown to be more susceptible to the MOG-encephalomyelitis model and showed poor clinical and biochemical outcomes, whereas pharmacological inhibition of MPO using the N-acetyl lysyltyrosylcysteine amide MPO inhibitor restored blood-brain barrier function and attenuated disease progression in the same encephalomyelitis model [26]. Here, MPO is linked to encephalomyelitis.