Furthermore, pharmacological inhibition of MPO using the cyclic nitroxide, 4-methoxy-2,2,6,6-tetramethyl-piperidin-1-yl-oxyl (4-methoxy-TEMPO) as a competitive substrate [11] or the thioxanthene, AZD3241, a specific pharmacological inhibitor of MPO [12], all abrogated disease indices during experimental colitis. This evidence concerns the gene MPO and colitis.