NPM1 and leukemia: Moreover, recognizing the heightened susceptibility of KMT2A-rearranged (KMT2Ar) leukemias to apoptosis induction through BCL2 inhibition, recent observations have shown synergistic activity in models of KMT2Ar or NPM1-mutated (NPM1mt) leukemia with dual Bcl-2 and menin inhibition [156].