S100B and melanoma: We also examined the potential role of this lipid panel in predicting metastasis by combining the levels of these three lipids with the plasma levels of serum lactate dehydrogenase (LDH) (as recommended by the American Joint Committee on Cancer (AJCC) revised melanoma staging guidelines) and the calcium-binding acidic cytoplasmic protein S100B, which is a well-known melanoma marker.