Additionally, transcription factors such as FOXC1, which has been associated with the development of multiple tumors, TBX3, associated with Ulna-Mamma Syndrome, and TEAD1, linked to Neurofibroma and Spindle Cell Rhabdomyosarcoma, could be considered targets for drug repositioning. This evidence concerns the gene TBX3 and spindle cell rhabdomyosarcoma.