Transcriptional subtypes of SCLC were determined based on next-generation sequencing (NGS) at the RNA level, identifying distinct categories such as SCLC-A (ASCL1-driven), SCLC-N (NEUROD1-driven), SCLC-P (POU2F3-driven), and SCLC-I (inflamed). The gene discussed is NEUROD1; the disease is small cell lung carcinoma.