Thus, the group of animals that received dietary adenine had renal dysfunction, as evidenced by the plasma creatinine levels along with all of the hallmarks of the mineral disorder associated with CKD, i.e., markedly increased plasma levels of phosphorus, creatinine, PTH, and intact and c-terminal FGF23 and reduced renal Klotho expression. The gene discussed is FGF23; the disease is chronic kidney disease.