Additionally, in the A3SA_36 vs. A3SA_24 comparison, we noted the down-regulation of MyD88, a regulator of NF-κB, in ‘malaria (ko05144)’ and ‘shigellosis (ko05131)’, leading to the inhibition of the antibacterial NF-κB pathway (Figure 11). Here, NFKB1 is linked to shigellosis.