In this respect, low radiation doses and phosphoramide have been used to induce the expression of CXCR4 and CXCL-12 [193], block inhibitory cytokines and receptors such as CXCL12 and CXCL15 [194], and reduce the expression of the endothelin B receptor, a molecule that restrict immune cell infiltration in ovarian cancers [195] Currently, experimental studies in murine models have shown encouraging results on pancreatic cancer through the negative regulation of pro-tumor cytokines. Here, CXCL12 is linked to familial pancreatic carcinoma.