After artemether treatment at a dose of 20 mg/kg but not at 5 mg/kg, the levels of the lipid peroxidation product MDA (malondialdehyde) and antioxidant enzyme SOD (superoxide dismutase) reversed by approximately 25% in brain extracts of 3xTg-AD mice in comparison to untreated AD mice [82]. This evidence concerns the gene SOD1 and Alzheimer disease.