PICALM and Alzheimer disease: Further support for the anti-inflammatory effect of artemisinins in AD models was provided by a current publication showing that artesunate (32 mg/kg/day, i.p.)also suppressed the neuroinflammatory response in the hippocampus and cortex of Picalm+/−; 5XFAD mice, as indicated by the detection of significantly lower numbers of Iba1-positive microglia (by 28–25%) and GFAP-positive astrocytes (by 23–36%) [76].