These mice develop a progressive neuropathology, including intracellular (3–4 months of age) and extracellular Aβ deposits (6 months of age) and phosphorylated tau aggregates (10–12 months of age), which start in the hippocampus and then expanding to the neocortex, thus closely mimicking the development pattern of the pathology in the brain of humans with AD [64]. The gene discussed is MAPT; the disease is Alzheimer disease.