CASP3 and Alzheimer disease: Li et al. reported, in 2019, a reduced number of TUNEL-positive apoptotic neurons in the brain cortex of 10-month-old 3xTg-AD mice following treatment with 5 mg/kg or 20 mg/kg of artemether and in different Aβ1–42-exposed neuronal cell cultures (PC12, SH-SY5Y, mice primary cortical neurons) pretreated with artemether (10–100 μM), concomitant with decreased caspase 3 activity.