In this context, a study by Zhao et al. has convincingly demonstrated that DHA, the active metabolite of artemisinins corrected autophagy dysfunction in the initial stage of Aβ pathology in APPswe/PSEN1dE9 mice and in cell models of AD (N2a-APP and SH-SY5Y-APP) by acting on multiple targets within the autophagic process [99]. This evidence concerns the gene APP and Alzheimer disease.