In relation to epilepsy, the most important ones are IL-1R1 (receptor of IL-1b), TLR2, TLR3, and TLR4 (receptors of HMGB1 and LPS), which—through the activation of NF-kB—activate the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX2), IL-6, TNF, CCL2, and CXCL10, among other proinflammatory mediators (reviewed in [20,28]) (Figure 2). Here, PTGS2 is linked to epilepsy.