HTRA1 and age-related macular degeneration: Moreover, polymorphisms in the ARMS2/HTRA1 (rs10490924 and rs11200638) locus are significantly associated with early and late AMD; however, instead of this locus, complement factor components (C2, CFH) and complement factor B (CFB) have not shown a positive correlation with AMD abnormalities [95] (Figure 4).