IRS1 and type 2 diabetes mellitus: With respect to the genes observed to be downregulated in our HFD + STZ model, the following genes were also correlated with human T2D: Adhesion Regulating Molecule 1 (ADRM1), Sorting Nexin 1 (SNX1), Insulin Receptor Substrate 1 (IRS1), DR1 Associated Protein 1 (DRAP1), and Uroporphyrinogen Decarboxylase (UROD) [67].