LPIN1 and Alzheimer disease: The levels of the Lipin1 (Lpin1, p < 0.001) and CDP-diacylglycerol synthase 1 (Cds1, p < 0.05), which play a role in generating new PLs and TGs by converting PA to DG and CDP-DG, were significantly lower in the HF + AD than AD mice (Figure 6E).