Various growth factors and soluble agents present in the tumor microenvironment (TME), such as transforming growth factor-beta (TGF-β), interleukin-6 (IL-6), fibroblast growth factor (FGF), and hepatocyte growth factor (HGF), play crucial roles in tumor growth, therapy resistance, and the induction of stemness properties [86,87]. The gene discussed is TGFB1; the disease is neoplasm.