For instance, Notch1/DLL1 signaling differentiation between “non-neuroendocrine” and “neuroendocrine” cell types in small cell lung cancer (SCLC) highlights Notch’s role in modulating transitions between CSCs with stem-like features and more differentiated tumor cells, suggesting that a similar mechanism might be at play in CRC. This evidence concerns the gene NOTCH1 and small cell lung carcinoma.