Some of the newly identified genes that contribute to the understanding of CdLS include ANKRD11 (ankyrin repeat domain-containing protein 11-OMIM:611192), EP300 (interacting inhibitor of differentiation 1-OMIM: 605894), AFF4 (alf transcription elongation factor 4-OMIM:604417), TAF1 (rna polymerase ii, tata box-binding protein-OMIM: 313650), ARCN1 (coatomer protein complex-OMIM: 600820), ARID1B (at-rich interaction domain-containing protein 1b-OMIM: 614556), ASXL2 (asxl transcriptional regulator 2-OMIM: 612991), and BRD4 (bromodomain-containing protein 4-OMIM:608749) [3,7]. This evidence concerns the gene EP300 and Cornelia de Lange syndrome.