After analyzing the genotypes and alleles of STAT4 rs10181656, rs7574865, rs7601754, and rs10168266, we found that the STAT4 rs7601754 AA genotype and the A allele were statistically significantly less frequent in MS patients compared to the control group (63.0% vs. 76.5%, p = 0.003, 79.0% vs. 87.0%, p = 0.003, respectively). The gene discussed is STAT4; the disease is myeloid sarcoma.