Lastly, in intrahepatic cholestasis of pregnancy, a specific liver disorder typically emerging in the third trimester, elevated maternal serum and placental levels of galectin-3 suggest its involvement in the pathophysiology of this condition, pointing to galectin-3 as a potential initiator, diagnostic marker, and target for prevention strategies related to intrahepatic cholestasis of pregnancy [78]. Here, LGALS3 is linked to intrahepatic cholestasis.