Seven out of the nine cytokines evaluated were significantly increased in AP patients at T1, compared to HC, and decreased from T1 to T2 evaluations, including IL-6, IL-8, IL-10, VEGF, TNF-alpha, MCP-1, and EGF, while no differences were observed between T3 and T4 in terms of cytokine concentrations. The gene discussed is TNF; the disease is alkaline phosphatase measurement.