Schmidt et al., 2015 [36] reported that general obesity was associated with elevated serum levels of IL-10 and IFN-γ, confirming the upregulation of certain pro- and anti-inflammatory cytokines in individuals with obesity, while Charles et al., 2011 [37] reported that IL-10 was not associated with obesity. This evidence concerns the gene IL10 and obesity due to melanocortin 4 receptor deficiency.