As far as Sox10 is concerned, quite apart from its significance in conserving survival [179] and multipotency of NCCs at the early stages of embryogenesis in mice [180], it is later crucial for melanocytic specification in zebrafish (sox10) [181] and prevention of premature neuronal differentiation of NCCs in mice [182], thus revealing its role in the WS phenotype. This evidence concerns the gene SOX10 and Werner syndrome.