IL6 and obesity due to melanocortin 4 receptor deficiency: On the one hand, subclinical inflammation, which is found in type 2 diabetic patients, is characterized by elevated circulating levels of inflammatory markers and obesity and involves an excess of macronutrients in the adipose tissue, which favors the release of inflammation mediators such as interleukin 6 which stimulates the liver to synthesize and secrete CRP [21].