A case-control study in patients attending an LC clinic was conducted to determine the role of endothelial damage using biomarkers for endothelial cell damage (von Willebrand Factor Antigen (VWF:Wg), VWF propeptide (VWFpp), and soluble thrombomodulin (sTM)). Here, THBD is linked to laryngotracheoesophageal cleft.