On the other hand, disturbances in insulin action could be regarded as one of the multiple factors potentially contributing to the pathophysiology of schizophrenia; as evidence, researchers have demonstrated that systemic and brain-selective insulin action may produce significant dysregulation in multiple neurotransmitter pathways, including the glutamatergic, dopaminergic, and serotonergic pathways [38]. Here, INS is linked to schizophrenia.