As previously mentioned, in our cohort, only patients with the PAI-1 polymorphism (4G/4G homozygous) showed a significantly higher chance of experiencing pathology related to placental insufficiency (FGR and GH) (OR 12.70; 95% CI: 1.71–93.83; p = 0.013). This evidence concerns the gene SERPINE1 and placental insufficiency.