SERPINE1 and thrombophilia: Inherited thrombophilias include a range of mutations, notably including the factor V Leiden (FVL) mutation, prothrombin G20210A mutation, and deficiencies of protein C (PC), protein S (PS), and antithrombin (AT), as well as methylenetetrahydrofolate reductase enzyme (MTHFR) 1298 and 677 mutations, and Plasminogen activator inhibitor-1 (PAI-1) mutation [5,6].