MUC5AC and Nasal polyposis: In 1994, Bent and Kuhn published the major criteria for AFRS including nasal polyps, fungal elements present on staining, eosinophilic mucin without fungal invasion, type 1 hypersensitivity to fungi, and characteristic radiographic findings (unilaterally or asymmetric findings, bony remodeling, and heterogenous densities within the sinuses) [68].