Toll-like receptors (TLR3 and TLR7) and cytosolic RNA sensors (RIG-I: retinoic acid-inducible gene I and MDA-5: melanoma differentiation-associated protein 5) are involved in the first steps of the cellular response to viral infection, recognizing the replication intermediates and viral RNA of SARS-CoV-2 [8]. Here, RIGI is linked to viral infectious disease.