The distribution of the genotype frequencies of the OAS3 rs2285932 variant in the study groups showed that the genotypes C/C, C/T, and T/T were present in 81.4%, 18.6%, and 0% of the participants in the symptomatic group, and in 64.7%, 29.4%, and 5.9% in the asymptomatic patients with COVID-19 (p = 0.039). Here, OAS3 is linked to COVID-19.