IDH2 and neoplasm: In particular, a 2018 Classe et al. integrative, multi-omics-based analysis of 59 ONB tumors identified two distinct tumor subgroups, including the IDH2 R172 mutation-enriched basal-like subtype, as well as the neural-like subtype with genome-wide reprogramming and loss of DNA methylation at the enhancers of DNA axonal guidance genes [60].