Rare causes of autoimmune optic neuropathies, such as glial fibrillary acidic protein (GFAP) and collapsin response-mediator protein 5 (CRMP5) autoimmunity, should also be considered in patients presenting with bilateral painless optic neuropathy associated with optic disc edema [70,71]. This evidence concerns the gene DPYSL5 and Optic neuropathy.