GPT and Cirrhosis: Although the recommendations slightly differ, antiviral treatment is usually indicated when chronic active hepatitis B disease is evident and at least one of the following criteria is fulfilled: (i) presence of advanced fibrosis or cirrhosis, (ii) HBV DNA level above at least 2000 IU/mL and (iii) persistently or repeatedly abnormal ALT/AST levels [13,14,26].