Neutrophils, dendritic cells, keratinocytes, macrophages, and various pro-inflammatory cytokines such as IL-6, IL-17, and TNF are key components of the innate immune response against the fungal infection, while cell-mediated immunity increases epidermal proliferation, promotes cell turnover, and ultimately, facilitates the elimination of fungi [40]. The gene discussed is IL6; the disease is fungal infectious disease.