In this study, the supplementation of extract containing 320.4 mg of anthocyanins (166.4 mg cyanidin and 121.7 delphinidin) alleviated the high-fat meal-induced postprandial dysmetabolism, including (i) increases in plasma lipopolysaccharides (LPS) and LPS-binding protein (endotoxemia); (ii) plasma glucose and triglyceride increases; (iii) oxidative stress biomarkers -TNF-α and NADPH oxidase 4 (NOX4) upregulation in peripheral blood mononuclear cells (PBMC); and (iv) insulin signaling biomarkers c-Jun N-terminal kinases (JNK1/2) activation in PBMC. This evidence concerns the gene NOX4 and serum lipopolysaccharide activity.